Phenyl-substituted alkenylcarboxylic acid guanidides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them

US6005010A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Jan-Robert Schwark · Frankfurt am Main, DE
• Joachim Brendel · Bad Vilbel, DE
• Heinz-Werner Kleemann · Bischofsheim, DE
• Hans-Jochen Lang · Hofheim, DE
• Andreas Weichert · Egelsbach, DE
• Hans-Willi Jansen · Niedernhausen, DE
• Wolfgang Scholz · Beverly, US

Key dates

• Filing date: Aug 20, 1997
• Grant date: Dec 21, 1999
• Expiry date: Aug 20, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## where T is ##STR2## and R(A), R(B), R(C), R(D), R(E), R(F), x and y have the meanings indicated in the claims, and their pharmaceutically acceptable salts are effective inhibitors of the cellular sodium-proton antiporter (Na.sup.+ /H.sup.+ exchanger). These compounds are therefore outstandingly suitable for treatment of all illnesses which are to be attributed to increased Na.sup.+ /H.sup.+ exchange.