Process for preparing pyrrolidine derivatives
US6005119A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 5, 1999 |
| Grant date | Dec 21, 1999 |
| Priority date | — |
| Expiry date | Apr 5, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D207/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
It is an object of the present invention to provide a process for producing an pyrrolidine derivative of general formula (2) or a salt thereof in a simple and economical manner and with good productivity and high yields. The present invention consists in a process for producing a pyrrolidine derivative of the general formula (2) or a salt thereof which comprises subjecting a compound of the general formula (1) to hydrogenolysis using a metal catalyst in the presence of at least one protic acid selected from the group consisting of hydrochloric acid, sulfuric acid, phosphoric acid, p-toluenesulfonic acid, methanesulfonic acid, acetic acid, n-butyric acid, trifluoroacetic acid and oxalic acid. ##STR1## R represents a 1-cyano-1,1-diphenylmethyl, 1-carbamoyl-1,1-diphenylmethyl, n-butyryloxy, methanesulfonyloxy or p-toluenesulfonyloxy group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.