Aromatic keto-acids and their derivatives as inhibitors of matrix metalloproteinases
US6008220A · kind A · utility
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12Claims
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Key dates
| Filing date | Jun 8, 1998 |
| Grant date | Dec 28, 1999 |
| Priority date | — |
| Expiry date | Jun 8, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Aromatic keto-acid compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, treatment of burns, decubital ulcers, wound healing, cancer, arthrities, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.