Arylthiazolidinedione derivatives

US6008237A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Soumya P. Sahoo · Old Bridge, US
• Richard L. Tolman · Hackettstown, US
• Wei Han · Beaverton, US
• Jeffrey P. Bergman · Tenafly, US
• Conrad Santini · Hackettstown, US
• Victoria K. Lombardo · Montgomery, US
• Ranjit C. Desai · Colonie, US
• Julia Boueres · Willingboro, US
• Dominick F. Gratale · Edison, US

Key dates

• Filing date: Dec 17, 1998
• Grant date: Dec 28, 1999
• Expiry date: Dec 17, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Substituted 5-aryl-2,4-thiazolidinediones are potent agonists of PPAR, and are therefore useful in the treatment, control or prevention of diabetes, hyperglycemia, hyperlipidemia (including hypercholesterolemia and hypertriglyceridemia), atherosclerosis, obesity, vascular restenosis, and other P.alpha., .delta. and/or .gamma. mediated diseases, disorders and conditions.