Resolution of 1-azabicyclo[2.2.2]octan-3-amine, 2-(diphenylmethyl)-n-[[2-methoxy-5-(1-methylethyl)phenyl]methyl]
US6008357A · kind A · utility
1Cited by
3References
14Claims
0Family size
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Key dates
| Filing date | Dec 16, 1997 |
| Grant date | Dec 28, 1999 |
| Priority date | — |
| Expiry date | Dec 16, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P29/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process for resolving 1-azabicyclo[2.2.2]octan-3-amine, (2-diphenylmethyl)-N-[[2-methoxy-5-(1-methylethyl)phenyl]methyl] in which 1-azabicyclo[2.2.2]octan-3-amine, (2-diphenylmethyl)-N-[[2-methoxy-5-(1-methylethyl)phenyl]methyl] is reacted with 1R-(-)-10-camphorsulfonic acid in a solvent capable of dissolving both the foregoing reactants and selectively dissolving the camphorsulfonic acid salt of the corresponding (2R, 3R) enantiomer relative to the (2S, 3S) enantiomer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.