Therapeutic use of bFGF to treat conditions involving adhesion of cytotoxic white cells to endothelium
US6010712A · kind A · utility
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22Claims
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Key dates
| Filing date | Aug 29, 1997 |
| Grant date | Jan 4, 2000 |
| Priority date | — |
| Expiry date | Aug 29, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of treating a condition involving vascular adhesion of cytotoxic white cells by (a) identifying an animal suspected of having a condition involving vascular adhesion of cytotoxic white cells and (b) administering to the animal an amount of bFGF sufficient to decrease cell surface expression of ICAM-I or VCAM-I on endothelial cells, thereby reducing adhesion of cytotoxic white cells to vascular endothelium.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.