Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments

US6013662A · kind A · utility

Assignee

• RHONE-POULENC RORER S.A. · FR

Inventors

• Jean-Dominique Bourzat · Saint-Mandé, FR
• Alain Commer.cedilla.on · Vitry-sur-Seine, FR
• Norbert Dereu · Viry-Châtillon, FR
• Patrick Mailliet · Fontenay-sous-Bois, FR
• Fabienne Sounigo-Thompson · Paris, FR
• Jean-Paul Martin · Colombes, FR
• Marc Capet · Melesse, FR
• Michel Cheve · Paris, FR

Key dates

• Filing date: Dec 29, 1997
• Grant date: Jan 11, 2000
• Expiry date: Dec 29, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel products of formula (I), their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments. ##STR1## In the formula (I), the following substituents are among the preferred: Ar represents a substituted or condensed phenyl radical or a polycyclic or heterocyclic aromatic radical, R represents a radical of general formula --(CH.sub.2).sub.m --X.sub.1 --(CH.sub.2).sub.n --Z in which X.sub.1 =single bond, O, S; m=0, 1; n=0, 1, 2; it being possible for the CH.sub.2 radicals to be substituted; Z represents carboxyl, COOR.sub.6 (R.sub.6 =alkyl), CON(R.sub.7)(R.sub.8) (R.sub.7 =hydrogen or alkyl and R.sub.8 =hydrogen, hydroxyl, arylsulphonyl, heterocyclyl, optionally substituted amino, optionally substituted alkyloxy or optionally substituted alkyl), PO(OR.sub.9).sub.2 (R.sub.9 =hydrogen or alkyl), an --NH--CO--T (T=hydrogen or optionally substituted alkyl) radical, or else PA1 a ##STR2## radical, R.sub.1 and R.sub.2 =hydrogen or halogen or alkyl, alkyloxy which is optionally substituted, alkylthio, alkyloxycarbonyl or else R.sub.1 and R.sub.2, at the ortho position with respect to one another, form an optionally substituted heterocy…