Process for the preparation of enantiomerically pure 3-hydroxyoctanedioic acid diesters by asymmetric catalytic hydrogenation

US6013833A · kind A · utility

Assignee

• Asta Medica Aktiengesellschaft · DE

Inventors

• Rainer Gewald · Dresden, DE
• Gunter Laban · Dresden, DE

Key dates

• Filing date: Mar 6, 1998
• Grant date: Jan 11, 2000
• Expiry date: Mar 6, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C69/675
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a process for the preparation of compounds of the general formula I ##STR1## in which R.sup.1 and R.sup.2 are identical or different and are a C.sub.1 -C.sub.20 -alkyl group, C.sub.3 -C.sub.12 -cycloalkyl group, C.sub.7 -C.sub.12 -aralkyl group or a mono- or binuclear aryl group, in which a ketone of the formula III or IV ##STR2## in which R.sup.1 and R.sup.2 have the above meaning, is asymmetrically hydrogenated.