Reagents for use as calibrators and controls
US6015662A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 23, 1996 |
| Grant date | Jan 18, 2000 |
| Priority date | — |
| Expiry date | Jan 23, 2016 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/96
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to the use of a reagent that binds specifically to a predetermined ligand, contains one or more antibody constant region epitopes, and is uniform in specificity and affinity. The reagent can be produced continually, in the manufacture of calibrators (standards) and/or controls for diagnostic kits designed to qualitatively or quantitatively measure antibodies specific for a desired ligand. For example, the present invention encompasses recombinant mouse-human chimeric antibodies which may be used as calibrators (standards) and/or positive controls in assays and kits which measure human antibodies. Any species may be used in creating the chimeric antibodies, and the presence of any corresponding species of antibody may be detected.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.