Transgenic fish and a method of harvesting islet cells therefrom
US6015713A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 22, 1996 |
| Grant date | Jan 18, 2000 |
| Priority date | — |
| Expiry date | Mar 22, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2517/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to transgenic fish containing a humanized insulin gene which has been altered to secrete human insulin and its use in the treatment of diabetes. In the transgenic fish of the present invention, the fish insulin gene has been modified to code for human insulin gene while leaving the regulatory sequences of fish insulin gene intact. Islet transplantation may provide the meticulous glycemia control required in the treatment of diabetes. The islet tissue of the present invention offers an inexpensive and a nearly unlimited supply of human insulin-producing tissue and therefore, may be useful in the treatment of diabetes. In this regard, an improved method of mass isolation of islet tissue is provided by the present invention. The present invention also provides the use of the humanized insulin gene to promote growth in fish.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.