Method of using tetracycline compounds to enhance interleukin-10 production
US6015804A · kind A · utility
25Cited by
6References
21Claims
0Family size
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Key dates
| Filing date | Sep 11, 1998 |
| Grant date | Jan 18, 2000 |
| Priority date | — |
| Expiry date | Sep 11, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention is a method of enhancing endogenous interleukin-10 production in mammalian cells and tissues, which includes administering an effective amount of a tetracycline derivative. The method also includes enhancing interleukin-10 production by administering an effective amount of the tetracycline derivative to a mammal. Preferred tetracycline compounds are tetracycline compounds which have been modified to reduce or eliminate their antimicrobial activity. The method can be used to treat medical conditions in mammals characterized by excessive IL-1 and TNF .alpha. production.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.