Intercalators having affinity for DNA and methods of use
US6015902A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 21, 1996 |
| Grant date | Jan 18, 2000 |
| Priority date | — |
| Expiry date | Oct 21, 2016 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2015/1477
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Intercalator compounds of formula I-T.sub.m as defined herein are provided which are comprised of intercalator moieties, or substituted intercalator moieties, having one or more functionalized chains, or moieties, and which compounds provide a high affinity for binding to the DNA molecule and show reduced self-quenching, while providing superior transport kinetics. The compounds have been found to provide enhanced fluorescence when bound to a DNA molecule within a fluorescent flow cytometry environment which is about eight to ten times brighter in fluorescence than "bis" structure conventional intercalating agents and other known intercalating agents utilized in flow cytometry environment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.