Stable reagents for the preparation of radio pharmaceuticals

US6015904A · kind A · utility

Inventors

• Michael Sworin · Tyngsborough, US
• Milind Rajopadhye · Westford, US
• Thomas D. Harris · Salem, US
• David Scott Edwards · Burlington, US
• Edward H. Cheesman · Lunenburg, US
• Shuang Liu · Schenectady, US

Key dates

• Filing date: Oct 23, 1997
• Grant date: Jan 18, 2000
• Expiry date: Oct 23, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2123/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides novel reagents for the preparation of radiopharmaceuticals useful as imaging agents for the diagnosis of cardiovascular disorders, infection, inflammation and cancer, diagnostic kits comprising said reagents and intermediate compounds useful for the preparation of said reagents. The reagents are comprised of stable hydrazone modified biologically active molecules that react with gamma emitting radioisotopes to form radiopharmaceuticals that selectively localize at sites of disease and thus allow an image to be obtained of the loci using gamma scintigraphy.