Efficient enantioselective addition reaction using an organozinc reagent
US6015926A · kind A · utility
6Cited by
7References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 11, 1998 |
| Grant date | Jan 18, 2000 |
| Priority date | — |
| Expiry date | May 11, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/07
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An efficient method for the preparation of key intermediate, in the synthesis of (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-ben zoxazin-2-one, a reverse transcriptase inhibitor is achieved using a chiral addition reaction to the 4-chloro-2-trifluoromethylketoaniline with an organozinc complex to give the desired alcohol. This instant method has broad applicability in the chiral addition to any prochiral ketone.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.