Combinatorial dihydrobenzopyran library

US6017768A · kind A · utility

Assignee

• PHARMACOPEIA, LLC · US

Inventors

• John J. Baldwin · Gwynedd Valley, US
• John Charles Reader · Princeton, US
• Lawrence W. Dillard · Hopewell, US
• Ge Li · Shanghai, CN
• Wenguang Zeng · Lawrenceville, US

Key dates

• Filing date: Oct 18, 1996
• Grant date: Jan 25, 2000
• Expiry date: Oct 18, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C40B40/00
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Combinatorial libraries are disclosed which are represented by Formula I: ##STR1## wherein: ##STR2## is a solid support; T'--L-- is an identifier residue; and --L'--II' is a ligand/linker residue. These libraries contain dihydrobenzopyrans of the formula ##STR3## which interact (i.e., as agonists or antagonists) with .alpha. adrenergic receptors, dopamine receptors, .sigma.-opiate receptors, and K.sup.+ channels and are inhibitors of carbonic anhydrase isozymes. They are useful in the treatment of ocular diseases such as glaucoma.