Nucleic acid respiratory syncytial virus vaccines
US6017897A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 18, 1997 |
| Grant date | Jan 25, 2000 |
| Priority date | — |
| Expiry date | Jul 18, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/18522
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Non-replicating vectors containing a nucleotide sequence coding for an F protein of respiratory syncytial virus (RSV) and a promoter for such sequence, preferably a cytomegalovirus promoter, are described for in vivo immunization. Such non-replicating vectors, including plasmids, also may contain a further nucleotide sequence located adjacent to the RSV F protein encoding sequence to enhance the immunoprotective ability of the RSV F protein when expressed in vivo. Such non-replicating vectors may be used to immunize a host against disease caused by infection with RSV, including a human host, by administration thereto, and may be formulated as immunogenic compositions with pharmaceutically-acceptable carriers for such purpose. Such vectors also may be used to produce antibodies for detection of RSV infection in a sample.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.