Patent · US Expired

Crystalline trimetrexate salts and the process for making the same

US6017921A · kind A · utility

5Cited by

3References

9Claims

0Family size

Assignee

U.S. Bioscience, Inc. · US

Inventors

Paul E. Kennedy · Tulsa, US
Ingomar Grafe · Nürnberg, DE
Johann Peter Morsdorf · Langenzenn, DE
Kurt H. Ahrens · Nürnberg, DE

Key dates

Filing date	Feb 4, 1998
Grant date	Jan 25, 2000
Priority date	—
Expiry date	Feb 4, 2018

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P35/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides for a crystalline form of trimetrexate either as a glucuronate, acetate, hydrochloride, methanosulfonate or lactate salt, which can be processed galenically as a stable, well-defined solid substance and processes for producing the crystalline forms. Such crystalline forms allow for prolonged stability in storage and for oral and intravenous administration of the drug.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.