Method of treating tumors using O-substituted fumagillol derivatives
US6017954A · kind A · utility
66Cited by
2References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 3, 1992 |
| Grant date | Jan 25, 2000 |
| Priority date | — |
| Expiry date | Sep 3, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to methods of using O-substituted fumagillol derivatives or salts thereof preferably, O-(N-chloroacetylcarbamoyl) fumagillol, O-(N-chloroacetylcarbamoyl)dihydrofumagillol or O-(N-chloracetylcarbamoyl)-6'b-hydroxyfumagillol, which have angiogenesis inhibitory activity, in the treatment and prevention of various diseases caused or advanced by abnormally hyperactive angiogenesis, especially various inflammatory diseases (rheumatism, psoriasis, etc.), diabetic retinopathy and cancer and other angiogenesis-dependent tumors, especially Kaposi's sarcoma, breast cancer, colon cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.