Process for the preparation of chiral, nonracemic (4-aryl-2,5-dioxoimidazolidin-1-yl) acetic acids

US6018053A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Wolfgang Holla · Kelkheim, DE
• Gerhard Beck · Frankfurt am Main, DE
• Bernhard Kammermeier · Frankfurt, DE
• Berndt Kulitzscher · Esselbach, DE
• Jurgen Michalowsky · Kelkheim, DE

Key dates

• Filing date: Jun 19, 1997
• Grant date: Jan 25, 2000
• Expiry date: Jun 19, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P7/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for the preparation of chiral, nonracemic compounds of the formula I ##STR1## in which R.sup.1 and R.sup.2 have the meanings indicated in claim 1 and which are useful intermediates for the preparation of pharmaceutical active compounds in which, for resolution, a salt is formed from the racemic compound of the formula I and a chiral, nonracemic amino compound. It furthermore relates to compounds of the formula I and esters thereof.