Transdermal protein delivery or measurement using low-frequency sonophoresis
US6018678A · kind A · utility
252Cited by
47References
7Claims
0Family size
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Key dates
| Filing date | Oct 19, 1995 |
| Grant date | Jan 25, 2000 |
| Priority date | — |
| Expiry date | Oct 19, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M2037/0007
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Applications of low-frequency (20 KHz) ultrasound enhances transdermal transport of high-molecular weight proteins. This method includes a simultaneous application of ultrasound and protein on the skin surface in order to deliver therapeutic doses of proteins across the skin. Examples demonstrate in vitro and in vivo administration of insulin (molecular weight 6,000 D), and in vitro administration of gamma interferon (molecular weight 17,000 D), and erythropoeitin (molecular weight 48,000 D).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.