Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging

US6019957A · kind A · utility

Assignee

• University of Tennessee Research Foundation · US

Inventors

• Duane D. Miller · Germantown, US
• Leonid I. Kirkovsky · Memphis, US
• James T. Dalton · Columbus, US
• Arnab Mukherjee · Memphis, US

Key dates

• Filing date: Jun 4, 1998
• Grant date: Feb 1, 2000
• Expiry date: Jun 4, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a radiolabeled non-steroidal compound having the formula: ##STR1## where R.sub.1, R.sub.2, and R.sub.3, are the same or different and are a radioactive or nonradioactive halogen, a nitro, a cyano, a carbamoyl, a hydrogen, a perfluoroalkyl, a haloalkylamido, an isothiocyanate, an azide, a diazocarbonyl, a substituted oxirane, or a .beta.-chloroethylamine; PA1 R.sub.4 is a hydrogen, an alkyl, or is joined to R.sub.5 ; PA1 R.sub.5 is a radioactive or nonradioactive halogen, a hydrogen, a hydroxy, an alkyl, a haloalkyl, an alkoxy, an acyloxy, an amino, an alkylamino, a thio, a thioalkyl, or is joined to R.sub.4 ; PA1 R.sub.6 is a hydrogen, an alkyl, a halogen, or a haloalkyl; PA1 A.sub.1 and A.sub.2 are the same or different, and each is a direct link or an alkylene; PA1 X.sub.1 is a radioactive or nonradioactive halogen, an oxygen, a sulfur, a sulphinyl, a sulphonyl, an amino, an alkylimino, or alkylene; PA1 R.sub.7 is a radioactive or nonradioactive halogen, a hydrogen, an alkoxy, a haloalkoxy, an acyloxy, a haloacyloxy, an aryloxy, a thioalkyl, a thioraryl, an alkylsulphinyl, an arylsulphinyl, an alkylsulphonyl, an arylsulphonyl, an amino, an alkylim…