Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis

US6019959A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Johannes Platzek · Berlin, DE
• Ulrich Niedballa · Berlin, DE
• Bernd Raduchel · Berlin, DE
• Wolfgang Schlecker · Berlin, DE
• Hanns-Joachim Weinmann · Berlin, DE
• Thomas Frenzel · Berlin, DE
• Bernd Misselwitz · Berlin, DE
• Wolfgang Ebert · Krefeld, DE

Key dates

• Filing date: Jun 29, 1998
• Grant date: Feb 1, 2000
• Expiry date: Jun 29, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D257/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Oligomeric compounds that contain perfluoroalkyl of general formula I EQU A--R.sup.F (I) in which PA1 A is a molecule portion that contains 2-6 metal complexes that are connected directly or via a linker to a nitrogen atom of an annular skeleton chain, and PA1 R.sup.F is a perfluorinated, straight-chain or branched carbon chain with formula --C.sub.n F.sub.2n E, in which E represents a terminal fluorine, chlorine, bromine, iodine, or hydrogen atom and n stands for numbers 4-30, are valuable compounds for diagnosis, especially as in-vivo contrast media.