Mutant enterotoxin effective as a non-toxic oral adjuvant
US6019982A · kind A · utility
24Cited by
1References
2Claims
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Key dates
| Filing date | Aug 26, 1994 |
| Grant date | Feb 1, 2000 |
| Priority date | — |
| Expiry date | Aug 26, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/825
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions are provided herein for the use of a novel mutant form of E. coli heat-labile enterotoxin which has lost its toxicity but has retained its immunologic activity. This enterotoxin is used in combination with an unrelated antigen to achieve an increased immune response to said antigen when administered as part of an oral vaccine preparation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.