Inhibitors of regulatory pathways

US6020121A · kind A · utility

Assignee

• Microcide Pharmaceuticals, Inc. · US

Inventors

• Ying Bao · Sunnyvale, US
• Amy Boggs · Menlo Park, US
• Pamela R. Contag · San Jose, US
• Nancy Anne Federspiel · Menlo Park, US
• Alan Hebert · Menlo Park, US
• Scott Hecker · Del Mar, US
• Francois Malouin · Los Gatos, US

Key dates

• Filing date: Jun 25, 1996
• Grant date: Feb 1, 2000
• Expiry date: Jun 25, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/05
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods are provided for screening for potential inhibitors of bacterial, or other microbial, global pathogenesis gene regulators and other gene regulators. Methods are also provided for treating microbial (e.g., bacterial) infections using such inhibitors. Also included are pharmaceutical compositions containing such inhibitors. The screening methods involve detecting whether the activity of a global pathogenesis gene regulator is altered in the presence of a test compound.