P53-regulated genes

US6020135A · kind A · utility

Assignees

• AFFYMETRIX, INC. · US
• THE TRUSTEES OF PRINCETON UNIVERSITY · US

Inventors

• Arnold J. Levine · Princeton, US
• Maureen Murphy · Glenside, US
• David Mack · Menlo Park, US
• Kurt Gish · San Francisco, US
• Edward Yat Wah Tom · Sacramento, US

Key dates

• Filing date: Mar 27, 1998
• Grant date: Feb 1, 2000
• Expiry date: Mar 27, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/136
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Many genes are identified as being p53-regulated which were not heretofore known to be p53-regulated. This includes both genes whose expression is induced and genes whose expression is repressed by the expression of wild-type p53. Monitoring expression of these genes is used to provide indications of p53 status in a cell. Such monitoring can also be used to screen for useful anti-cancer therapeutics, as well as for substances which are carcinogenic. Defects in p53 can be bypassed by supplying p53 induced genes to cells. Defects in p53 can also be bypassed by supplying antisense constructs to p53-repressed genes.