Crystal of a protein-ligand complex containing an N-terminal truncated eIF4E, and methods of use thereof
US6020162A · kind A · utility
1Cited by
6References
6Claims
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Key dates
| Filing date | Jun 12, 1998 |
| Grant date | Feb 1, 2000 |
| Priority date | — |
| Expiry date | Jun 12, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/4705
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A detailed three-dimensional structure for the least abundant of the general translation initiation factors in eukaryotes, eIF4E, complexed with a ligand is disclosed. The novel N-terminal truncated eIF4Es which were constructed so as to omit a significant portion of the flexible N-terminal tail of the eIF4E are also part of the present invention. In addition, the crystals of the protein-ligand complexes containing the N-terminal truncated eIF4Es are also included. Furthermore, methods of identifying antagonists of the eIF4E protein which can be used to regulate protein synthesis in cells are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.