Isolated nucleic acid molecules which encode mammalian or rodent 2,8 polysialyl transferases

US6020201A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Rita Gerardy-Schahn · Hiddenhausen, DE
• Minoru Fukuda · Oodu, JP
• Jun Nakayama · Matsumoto, JP
• Matthias Eckhardt · Hannover, DE

Key dates

• Filing date: Jul 24, 1997
• Grant date: Feb 1, 2000
• Expiry date: Jul 24, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A protein having polysialyl transferase activity, which a) is a product of a prokaryotic or eukaryotic expression of an exogenous DNA, b) is coded by the DNA sequence shown in SEQ ID No. 1, c) is coded by the DNA sequences which hybridize with the sequences SEQ ID No. 1 and/or SEQ ID No. 3, d) is coded by DNA sequences which if there was no degeneracy of the genetic code, would hybridize with the sequences defined in b) to c), and e) catalyzes the polycondensation of .alpha.-2,8-linked sialic acids, and its related nucleic acid molecules and fragments are useful for the production of therapeutic agents for tumor therapy.