GRF analogs with increased biological potency
US6020311A · kind A · utility
19Cited by
1References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 8, 1998 |
| Grant date | Feb 1, 2000 |
| Priority date | — |
| Expiry date | Sep 8, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to chimeric fatty body-GRF analogs with increased biological potency, their application as anabolic agents and in the diagnosis and treatment of growth hormone deficiencies. The chimeric fatty body-GRF analogs include an hydrophobic moiety (tail), and can be prepared, either by anchoring at least one hydrophobic tail to the GRF, in the chemical synthesis of GRF. The GRF analogs of the present invention are biodegradable, non-immunogenic and exhibit an improved anabolic potency with a reduced dosage and prolonged activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.