.beta.-sheet mimetics and use thereof as protease inhibitors
US6020331A · kind A · utility
19Cited by
1References
34Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jan 20, 1998 |
| Grant date | Feb 1, 2000 |
| Priority date | — |
| Expiry date | Jan 20, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/06139
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There are disclosed .beta.-sheet mimetics and methods relating to the same for imparting or stabilizing the .beta.-sheet structure of a peptide, protein or molecule. In one aspect, the .beta.-sheet mimetics are covalently attached at the end or within the length of the peptide or protein. The .beta.-sheet mimetics have utility as protease inhibitors generally, including activity as serine protease inhibitors such as thrombin, elastase and Factor X.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.