Electronegative-substituted long chain xanthine compounds

US6020337A · kind A · utility

Assignee

• CELLO THERAPEUTICS, INC. · US

Inventors

• Alistair J. Leigh · Edmonds, US
• John Michnick · Seattle, US
• Anil Kumar · Seattle, US
• J. Peter Klein · Vashon, US
• Gail E. Underiner · Malvern, US

Key dates

• Filing date: Sep 16, 1997
• Grant date: Feb 1, 2000
• Expiry date: Sep 16, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Therapeutic compounds, including resolved enantiomers and/or diastereomers, hydrates, salts, solvates and mixtures thereof, having a formula: ##STR1## wherein R.sub.0 is selected from the group consisting of hydrogen, halo, hydroxyl, amino, substituted or unsubstituted C.sub.(1-10) alkyl, C.sub.(2-10) alkenyl, cyclic or heterocyclic groups, wherein the substituents of substituted C.sub.(1-10) alkyl, C.sub.(2-10) alkenyl are other than halo; n is an integer from one to sixteen; R.sub.1, R.sub.2, and R.sub.3 are independently selected from the group consisting of a halo; haloacetoxy; hydrogen; hydroxy; oxo; --N.dbd.C.dbd.S; --N.dbd.C.dbd.O; --0--C.tbd.N; --C.tbd.N; --N.dbd.N.dbd.N; and --C--(R.sub.5).sub.3, R.sub.5 being independently a halo or hydrogen, at least one R.sub.5 being halo, at least one of R.sub.1, R.sub.2, and R.sub.3 being halo, cyano, isocyano, isothiocyano, azide or haloacetoxy group; R.sub.4 is hydrogen, C.sub.(1-6) alkyl, C.sub.(1-6) alkenyl, cyclo C.sub.(4-6) alkyl, or phenyl; one or more hydrogen atoms of (CH.sub.2).sub.n --CH.sub.a --CH.sub.b --CH.sub.c may be replaced with: i) at least one of halogen atom, hydroxyl, oxo, substituted or unsubstituted C.sub.(1-10…