Nitrogen containing heteroaromatics as factor Xa inhibitors

US6020357A · kind A · utility

Assignee

• Dupont Pharmaceuticals · US

Inventors

• Donald J. P. Pinto · Nazareth, US
• James R. Pruitt · Landenberg, US
• Joseph Cacciola · Newark, US
• John M. Fevig · McKeesport, US
• Qi Han · Wilmington, US
• Michael J. Orwat · New Hope, US
• Mimi L. Quan · Newark, US
• Karen A. Rossi · Newtown, US

Key dates

• Filing date: Dec 22, 1997
• Grant date: Feb 1, 2000
• Expiry date: Dec 22, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D may be C(.dbd.NH)NH.sub.2, which are useful as inhibitors of factor Xa.