Rigid bifunctional chelating agents
US6022522A · kind A · utility
16Cited by
1References
1Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 23, 1998 |
| Grant date | Feb 8, 2000 |
| Priority date | — |
| Expiry date | Mar 23, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K51/1093
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Bicyclo[2.2.2]octane-2,3 diamine-N,N,N',N'-tetraacetic acids (BODTA) and bicyclo[2.2.1]heptane-2,3 diamine-N,N,N',N'-tetraacetic acid (BHDTA) are chelating agents useful in forming detectably labeled bioconjugate compounds for diagnostic and therapeutic purposes. New compounds and processes of forming BODTA and BHDTA are disclosed. Radioimmunoconjugates of the present invention show high and prolonged tumor uptake with low normal tissue uptakes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.