Lantibiotic related to actagardine, and processes for the preparation and use thereof

US6022851A · kind A · utility

Assignee

• Hoechst Marion Roussel Deutschland GmbH · DE

Inventors

• Laszlo Vertesy · Eppstein, DE
• Herbert Kogler · Königstein, DE
• Matthias Schiell · Brechen, DE
• Joachim Wink · Rödermark, DE

Key dates

• Filing date: Oct 14, 1998
• Grant date: Feb 8, 2000
• Expiry date: Oct 14, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a novel lantibiotic having the formula NH.sub.2 --R-actagardine, where NH.sub.2 --R is the radical of the amino acid alanine, which is formed by the microorganism Actinoplanes liguriae, DSM 11797 or Actinoplanes garbadiensis, DSM 11796 during fermentation, chemical derivatives of the lantibiotic, a process for its preparation and the use of the lantibiotics as pharmaceuticals.