Platelet specific therapeutic compound and method of treating
US6022854A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Apr 17, 1995 |
| Grant date | Feb 8, 2000 |
| Priority date | — |
| Expiry date | Apr 17, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A therapeutic compound comprises a KGD-containing peptide, tandem repeats thereof, combinations thereof, or combinations thereof with an RGD-containing peptide or tandem repeats thereof, or peptide analogues or non-peptide organic analogues of the RGD and KGD tripeptides, and a pharmaceutical agent. A therapeutic composition comprises the compound of this invention and a pharmaceutically acceptable carrier. A polydeoxyribonucleotide comprises a DNA sequence, and a polyribonucleotide comprises an RNA sequence, encoding the compound of the invention, where the pharmaceutical agent is a peptide. A self-replicating DNA carries the polydeoxyribonucleotide described above and a transformed host cell comprises the self-replicating DNA. Therapeutic platelets are loaded with a therapeutic compound comprising a peptide comprising RGD or KGD, peptide analogues or organic analogues thereof, tandem repeats thereof, or combinations thereof, and a pharmaceutical agent operatively linked to the peptide. A method of delivering a pharmaceutical agent to a site afflicted with a disease comprises administering an effective amount of the therapeutic platelets or the therapeutic compound comprising RGD …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.