Substituted pyridylamino indoles

US6022880A · kind A · utility

Assignee

• Hoechst Marion Roussel · FR

Inventors

• Richard C. Effland · Bound Brook, US
• Joseph T. Klein · Bound Brook, US
• Lawrence L. Martin · Lebanon, US
• Gregory M. Shutske · Somerville, US
• Kevin J. Kapples · Little York, US
• John D. Tomer, IV · Perkasie, US

Key dates

• Filing date: Jul 28, 1997
• Grant date: Feb 8, 2000
• Expiry date: Jul 28, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There are disclosed various compounds of the formula below, ##STR1## where R, R.sub.1, W, X, Y and Z are as defined in the specification; which are useful for alleviating various memory dysfunctions such as Alzheimer's disease, as modulators of neurotransmitter functions such as serotonergic and adrenergic, and as such are useful as antidepressants, anxiolytics, atypical antipsychotics, antienmtics, and for the treatment of personality disorders such as obsessive compulsive disorder.