Nucleic acids internally-derivatized with a texaphyrin metal complex and uses thereof
US6022959A · kind A · utility
4Cited by
22References
25Claims
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Key dates
| Filing date | Nov 20, 1997 |
| Grant date | Feb 8, 2000 |
| Priority date | — |
| Expiry date | Nov 20, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Texaphyrin metal complex-oligonucleotide and -oligonucleotide analog conjugates are provided where the texaphyrin is bound to an internal linkage of the oligonucleotide or oligonucleotide analog, the conjugates having catalytic activity for the hydrolysis of ribonucleic acid. Further, conjugates demonstrating catalytic turnover are described, the conjugates being especially effective under conditions where the concentration of RNA target exceeds that of available conjugate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.