Process for the preparation of 4-acetoxy-2.alpha.-benzoyloxy-5.beta., 20-epoxy-1, 7.beta.-10.beta.-trihydroxy-9-oxo-tax-11-en-13.alpha.-yl(2R,3S)-3-tert-b utoxy-carbonYlamino-2-hydroxy-3-phenylpropionate trihydrate
US6022985A · kind A · utility
39Cited by
1References
5Claims
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Key dates
| Filing date | Apr 25, 1997 |
| Grant date | Feb 8, 2000 |
| Priority date | — |
| Expiry date | Apr 25, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Process for the preparation of 4-acetoxy-2.alpha.-benzoyloxy-5.beta.,20-epoxy-1,7.beta., 10.beta.-trihydroxy-9-oxo-tax-11-en-13.alpha.-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate trihydrate, characterized in that the 4-acetoxy-2.alpha.-benzoyloxy-5.beta.,20-epoxy-1,7.beta.,10.beta.-trihydro xy-9-oxo-tax-11-en-13.alpha.-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate is crystallized from a mixture of water and an aliphatic alcohol containing 1 to 3 carbon atoms, and then the product obtained is dried under defined conditions of temperature, pressure and humidity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.