Lyophilized imaging agent formulation comprising a chemotactic peptide
US6024938A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Dec 24, 1997 |
| Grant date | Feb 15, 2000 |
| Priority date | — |
| Expiry date | Dec 24, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K51/1093
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A lyophilized imaging agent formulation and methods for making same are disclosed, such formulations comprise a targeting molecule such as antibody or chemotactic peptide, a linker such as diethylenetriaminepentaacetic acid (DTPA) or succinimidyl 6-hydrazinium nicotinate hydrochloride (SHNH), drying protectant such as mannitol, maltose or tricine, and excipient such as polysorbate 80, in citrate buffer. The formulations of the invention are lyophilized and may be stored stably for extended periods of time. Following reconstitution with diluent, the formulations are administered to a subject for scintigraphic imaging or therapeutic use. Also contemplated is a kit comprising a two-vial system wherein a first vial comprises a lyophilized formulation of imaging agent in the form of a lyophilized cake, and a second vial comprises a pharmaceutically acceptable carrier or diluent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.