Membrane anchor/active compound conjugate, its preparation and its uses

US6024964A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Gunther Jung · Tübingen, DE
• Karl-Heinz Wiesmuller · Tübingen, DE
• Jorg Metzger · Tübingen, DE
• Hans-Jorg Buhring · Lörrach, DE
• Gerhard Becker · Neckargemünd, DE
• Wolfgang Bessler · Offenburg, DE

Key dates

• Filing date: Jun 6, 1995
• Grant date: Feb 15, 2000
• Expiry date: Jun 6, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

According to certain embodiments, the invention relates to a method of producing antibodies employing an immunoconjugate produced by conjugating at least one membrane-anchoring compound with at least one partial sequence of a viral, bacterial, or protoral protein. The immunoconjugate has the advantage that it can be stored for a very long time even without cooling. According to certain embodiments, the invention relates to an immunoconjugate for the specific induction of cytotoxic T-lymphocytes which comprises a conjugate from at least one membrane anchor compound and a protein, containing at least one killer T-cell epitope, of a virus, a bacterium, a parasite or a tumor antigen, or at least one partial sequence containing at least one killer T-cell epitope of a viral, bacterial or parasite protein or of a tumor antigen.