Hydrophobic u-PAR binding site

US6025142A · kind A · utility

Assignees

• Boehringer Mannheim GmbH · DE
• Cancerforskningsfondet af 1989 · DK

Inventors

• Ulrich Pessara · Weilheim, DE
• Ulrich Weidle · Hersbruck, DE
• Bernhard König · Bobingen, DE
• Ulrich Kohnert · Habach, DE
• Ilse Bartke · Bernried, DE
• Keld Dan.o slashed. · Copenhagen, DK
• Michael Ploug · Copenhagen, DK
• Vincent Ellis · Copenhagen, DK

Key dates

• Filing date: Jun 2, 1995
• Grant date: Feb 15, 2000
• Expiry date: Jun 2, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to an antibody which inhibits the binding between u-PA and u-to an extent of at least 90% in an assay as defined in the specification, or an active fragment or immunological equivalent of said antibody. Examples of such antibodies are deposited Jul. 7, 1994 at Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSM) with accession numbers DSM ACC2178 and DSM ACC2179 under the terms and conditions of the Budapest Treaty. The invention furthermore relates to a method for detecting or quantifying u-or a glycosylation variant of u-in a sample by use of an antibody according to the invention. Furthermore, the invention relates to a method for the manufacture of a therapeutic agent for preventing or counteracting localized proteolytic activity using of an antibody of the invention as well as to use of an antibody according to the invention for the preparation of a diagnostic agent which is capable of targeting a diagnostic to a cell that contains a u-on the surface.