Monospecific antibodies against a subunit of fibrinogen
US6025148A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 1, 1997 |
| Grant date | Feb 15, 2000 |
| Priority date | — |
| Expiry date | Jul 1, 2017 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/75
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides monospecific antibodies which are specifically reactive with the .alpha.hd E subunit of fibrinogen or a fragment thereof, but not with other portions of the fibrinogen molecule. The invention also provides anti-.alpha..sub.E probes, including monospecific anti-.alpha..sub.E antibodies which have been detectably labeled. In addition, the invention provides methods of using the monospecific antibodies for detection of the .alpha..sub.E subunit and fragments thereof, as well as reagents and kits for performing the methods. Diagnostic methods for determining information associated with atherogenesis and/or thrombogenesis, as well as for determining information associated with pregnancy status or outcome. The invention further provides continuous cell lines which produce monospecific anti-.alpha..sub.E antibodies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.