Selectable vectors for human T cells

US6025153A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Bernhard Fleckenstein · Wiesenthau, DE
• Ralph Grassmann · Erlangen, DE

Key dates

• Filing date: Sep 18, 1992
• Grant date: Feb 15, 2000
• Expiry date: Sep 18, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/16443
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Selectable Herpesvirus saimiri vectors which have a selection gene inserted into a junction region of the L- and H-DNA are described. Vectors of this type are able persistently to infect human T cells and thus are suitable for the expression of foreign genes in human T cells. An additional advantage is that no infectious virus particles are produced during this.