Transgenic animal assay system for anti-cholinesterase substances
US6025183A · kind A · utility
11Cited by
13References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 6, 1997 |
| Grant date | Feb 15, 2000 |
| Priority date | — |
| Expiry date | Mar 6, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/0356
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides a transgenic animal assay system which provides a model system for testing for, and treatment of, cholinergic deficits and imbalances in mammals such as cognitive functioning in Alzheimer's patients, certain types of retinal photoreceptor degeneration, hematopoietic disorders, and screening for and susceptibility to anti-cholinesterase compounds. The transgenic animals and progeny thereof are transformed with a recombinant expression vector of the present invention. The recombinant expression vector comprises a DNA sequence encoding a heterologous cholinesterase (ChE) enzyme and promoter.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.