Methods and compositions for diagnosis and treatment of pathological conditions related to abnormal dopamine receptor expression
US6025193A · kind A · utility
25Cited by
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12Claims
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Key dates
| Filing date | Mar 14, 1997 |
| Grant date | Feb 15, 2000 |
| Priority date | — |
| Expiry date | Mar 14, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2984
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions are provided for diagnosing and treating pathological conditions related to a dopamine receptor abnormality. The methods comprise administering to a patient having such a pathological condition a plasmid encoding an oligonucleotide, antisense to one or more RNA molecules encoding one of the several dopamine receptors, thereby selectively controlling expression of one or more dopamine receptor subtypes, and alleviating the pathological conditions related to their expression. The vectors are targeted to specific regions of the brain via complexation with antibody studded liposomes.
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