Somatostatin agonists

US6025372A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Lihu Yang · Edison, US
• Arthur A. Patchett · Westfield, US
• Alexander Pasternak · Brookline, US
• Kevin T. Chapman · Emeryville, US
• James R. Tata · Westfield, US
• Liangqin Guo · Edison, US

Key dates

• Filing date: Apr 1, 1998
• Grant date: Feb 15, 2000
• Expiry date: Apr 1, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Somatostatin agonist compounds of formula I are disclosed: ##STR1## including pharmaceutically acceptable salts and hydrates thereof These compounds are useful in the treatment of diabetes, cancer, acromegaly, restenosis, depression, irritable bowel syndrome and pain. The compounds are potent with high selectivity toward the receptor subtype 2. Pharmaceutical compositions and methods of treatment are also included.