Synthesis of a hydrazone .beta.-keto ester by the reaction with a diazo ester
US6025492A · kind A · utility
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3References
23Claims
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Assignee
Inventors
Key dates
| Filing date | May 24, 1999 |
| Grant date | Feb 15, 2000 |
| Priority date | — |
| Expiry date | May 24, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C249/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to the synthesis of a hydrazone .beta.-keto ester by the reaction of an alkyl diazoester with a hydrazone aldehyde in the presence of a Lewis acid In a preferred embodiment, the hydrazone .beta.-keto ester is then converted into a pyridazinone compound by the reaction with an alkyl acid chloride in the presence of a base, followed by acidification. A process for the production of a hydrazone aldehyde, which comprises contacting a hydrazine and glyoxal, is also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.