High-efficiency AA V helper functions
US6027931A · kind A · utility
19Cited by
5References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 30, 1998 |
| Grant date | Feb 22, 2000 |
| Priority date | — |
| Expiry date | Jun 30, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/20
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides methods and compositions for producing high titer preparations of recombinant AAV ("rAAV") virions. The compositions of the present invention include AAV helper function systems and host cells. The present invention also includes methods of using AAV helper function vectors that effect the production of only small amounts of the long forms of Rep protein, and rAAV virions produced by such methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.