Peptide inhibitors of a phosphotyrosine-binding domain containing protein

US6028053A · kind A · utility

Assignees

• MOUNT SINAI HOSPITAL · CA
• Asahi Chemical Industry Co., Ltd. · SS

Inventors

• Peter van der Geer · Solana Beach, US
• Sandra Eileen Wiley · Solana Beach, US
• Gerald Gish · Truro, CA
• Anthony Pawson · Toronto, CA
• Kazunori Toma · Tokyo, JP

Key dates

• Filing date: Apr 22, 1998
• Grant date: Feb 22, 2000
• Expiry date: Apr 22, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A peptide of the formula (I): X.sup.1 -A.sup.1 -A.sup.2 -X.sup.2 -Asn-X.sup.3 -X.sup.4 -P.Tyr-X.sup.5 -X.sup.6 -X.sup.7 -X.sup.8, wherein X.sup.1 represents Lys, Arg, His, Ser, Thr, Tyr, Asn, Leu, Val or Glu, A.sup.1 represents Trp, Leu, Ala, Ser, Ile, Glu, Met, Gly, Cys, Phe, Pro or Val, and A.sup.2 represents Ala, Val, Leu, Ile, Ser, Met, Phe, Gly, Cys, Trp or Pro, X.sup.2 represents Glu, Asn, Tyr, Thr, Ser, Asp or Ile, X.sup.3 represents Pro, Met, Trp, Phe, Ala, Lys, Val, Leu, Ile, Gly or Ser, X.sup.6 represents Ser, Thr, Tyr, Asn, Glu, Met, Ala, Leu, Val or Gly, X.sup.7 represents Asp, Glu, Ala, Val, Leu, Ile, Gly, Cys, Phe, Trp, Met, Pro, Ser or Asn and X.sup.8 which may be present or absent represents Phe, Trp, Pro, Leu, Ala, Val, Ile, Gly, Cys, Met, Asp, Ser or Arg which interferes with the interaction of a PTB domain containing protein with a PTB domain binding site, and truncations and analogues of the peptide.