Methods and compositions for regulating nuclear trafficking of proteins
US6028058A · kind A · utility
7Cited by
1References
4Claims
0Family size
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Key dates
| Filing date | Jul 21, 1997 |
| Grant date | Feb 22, 2000 |
| Priority date | — |
| Expiry date | Jul 21, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/503
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods are provided to regulate the trafficking of nuclear proteins, including the high molecular weight forms of FGF-2, to the nucleus. A nuclear trafficking component, which is approximately 29 kD, is identified as binding to and regulating nuclear localization of FGF-2. Inhibitors of the binding of the 29 kD component and FGF-2 are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.