Succinyl hydroxamic acid, N-formyl-N-hydroxy amino carboxylic acid and succinic acid amide derivatives as metalloprotease inhibitors
US6028110A · kind A · utility
7Cited by
11References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 22, 1996 |
| Grant date | Feb 22, 2000 |
| Priority date | — |
| Expiry date | Nov 22, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C323/60
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A pharmaceutical or veterinary composition comprising a compound of formula I ##STR1## wherein X is a --CO.sub.2 H group and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 are as defined in the specification, or a salt, hydrate or solvate thereof, and a pharmaceutically or veterinarily acceptable excipient or carrier. A method of treatment of diseases or conditions mediated by MMPs in mammals, such as rheumatoid arthritis, osteoarthritis, periodontitis, gingivitis, corneal ulceration or tumour invasion by secondary means, by administering to the mammal an effective amount of the composition.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.